Question:
I am leaving home on the day prior to the night of the bedikah and arrive to the hotel on the bedikah night. Where and when should I make the bedikah?
Answer:
Do bedikah at home the night before you leave, without a berachah, and bedikah in the hotel room, with a berachah.
Sources:
Concerning a hotel room, see Shevet Halevi 10:68 (who writes that there is a full obligation, and one should check with a berachah).